Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1707549..1708123 Replicon chromosome
Accession NZ_CP097796
Organism Pasteurella multocida strain 40540

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag M9420_RS08085 Protein ID WP_014667974.1
Coordinates 1707549..1707833 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag M9420_RS08090 Protein ID WP_014391174.1
Coordinates 1707830..1708123 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9420_RS08065 (M9420_08065) 1703011..1705197 + 2187 WP_014667973.1 S8 family peptidase -
M9420_RS08070 (M9420_08070) 1705497..1705682 + 186 WP_016534551.1 hypothetical protein -
M9420_RS08075 (M9420_08075) 1705994..1706255 + 262 Protein_1556 hypothetical protein -
M9420_RS08085 (M9420_08085) 1707549..1707833 + 285 WP_014667974.1 addiction module protein Toxin
M9420_RS08090 (M9420_08090) 1707830..1708123 + 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
M9420_RS08095 (M9420_08095) 1708521..1709198 - 678 WP_014391173.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
M9420_RS08100 (M9420_08100) 1709216..1709683 - 468 WP_014391172.1 PTS sugar transporter subunit IIA -
M9420_RS08105 (M9420_08105) 1709728..1711518 - 1791 WP_014391171.1 PTS ascorbate-specific subunit IIBC -
M9420_RS08110 (M9420_08110) 1711867..1712958 + 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1706094..1706255 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T246244 WP_014667974.1 NZ_CP097796:1707549-1707833 [Pasteurella multocida]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT246244 WP_014391174.1 NZ_CP097796:1707830-1708123 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References