Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 317718..319362 Replicon chromosome
Accession NZ_CP097794
Organism Pasteurella multocida strain 28606

Toxin (Protein)


Gene name hipA Uniprot ID V4NI19
Locus tag M9413_RS01520 Protein ID WP_005752891.1
Coordinates 317718..319025 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M9413_RS01525 Protein ID WP_250265460.1
Coordinates 319027..319362 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9413_RS01510 (M9413_01510) 313718..316300 + 2583 WP_250265458.1 DNA mismatch repair protein MutS -
M9413_RS01515 (M9413_01515) 316363..317499 - 1137 WP_284346604.1 anhydro-N-acetylmuramic acid kinase -
M9413_RS01520 (M9413_01520) 317718..319025 + 1308 WP_005752891.1 HipA domain-containing protein Toxin
M9413_RS01525 (M9413_01525) 319027..319362 + 336 WP_250265460.1 helix-turn-helix transcriptional regulator Antitoxin
M9413_RS01530 (M9413_01530) 319458..320126 - 669 WP_083004360.1 NAD(P)H-dependent oxidoreductase -
M9413_RS01535 (M9413_01535) 320167..321534 - 1368 WP_083004363.1 oxygen-independent coproporphyrinogen III oxidase -
M9413_RS01540 (M9413_01540) 321558..321986 - 429 WP_005719208.1 DUF2489 domain-containing protein -
M9413_RS01545 (M9413_01545) 321992..322561 - 570 WP_250265461.1 Der GTPase-activating protein YihI -
M9413_RS01550 (M9413_01550) 322625..323284 - 660 WP_150331928.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-375)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50526.31 Da        Isoelectric Point: 4.9118

>T246242 WP_005752891.1 NZ_CP097794:317718-319025 [Pasteurella multocida]
MEKLTLQIYLEQAWCDLAFLYFDSETYQLCNFEYLTDYVVQHYGKTGEHAVSLNYPVNVFIDDTTSLWSWLSDIAPAGAS
RRYWLEALDIKQESEEKQQFLLLKHAAISPIGNLRIKDAVPEQVEVRLFDLDKAKDRQSDFLEYVNQSGAMVGGATGAGG
EAPKLLLKRRENQVWIDNQQQGQDQDVSYLVKYPRGNYSPIDCDILRAEYHYYQELAQLGFDTIDTTRMRLEEGKRYPSL
WLPRFDIVQREGKTHRLAFESVYSLLQKQGGVLDHETTLRQLIERISTARLQFAQTDFVIEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQRIWLAPIYDFAPMRADPEGIIRTTTWQTKGEYPQEFAGEYHFERIAEVLADLVEPTLLMQELRRLAGSLVD
LKSRLVQRNLPQSILDFPAIGFDYLPEKLKKWGLI

Download         Length: 1308 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12584.65 Da        Isoelectric Point: 10.5259

>AT246242 WP_250265460.1 NZ_CP097794:319027-319362 [Pasteurella multocida]
MQITRRNASTKGASVAEIDRKKVRNEIIQAMLMGELSQGEALRKLRIEMFGINQQHYIQLVKVSRQTLSNIENDKGNYSV
ETINKVFKPFGLEFGLVPVSKALLKELFSTT

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V4NI19

Antitoxin

Source ID Structure

References