Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1766999..1767573 Replicon chromosome
Accession NZ_CP097793
Organism Pasteurella multocida strain 21275

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag M9417_RS08640 Protein ID WP_014667974.1
Coordinates 1766999..1767283 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag M9417_RS08645 Protein ID WP_014391174.1
Coordinates 1767280..1767573 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9417_RS08620 (M9417_08620) 1762462..1764648 + 2187 WP_079157817.1 S8 family peptidase -
M9417_RS08625 (M9417_08625) 1764948..1765100 + 153 WP_014391177.1 hypothetical protein -
M9417_RS08630 (M9417_08630) 1765444..1765705 + 262 Protein_1666 hypothetical protein -
M9417_RS08640 (M9417_08640) 1766999..1767283 + 285 WP_014667974.1 addiction module protein Toxin
M9417_RS08645 (M9417_08645) 1767280..1767573 + 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
M9417_RS08650 (M9417_08650) 1767970..1768647 - 678 WP_014391173.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
M9417_RS08655 (M9417_08655) 1768665..1769132 - 468 WP_014391172.1 PTS sugar transporter subunit IIA -
M9417_RS08660 (M9417_08660) 1769177..1770967 - 1791 WP_014391171.1 PTS ascorbate-specific subunit IIBC -
M9417_RS08665 (M9417_08665) 1771316..1772407 + 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1765544..1765705 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T246241 WP_014667974.1 NZ_CP097793:1766999-1767283 [Pasteurella multocida]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT246241 WP_014391174.1 NZ_CP097793:1767280-1767573 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References