Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 506663..508307 Replicon chromosome
Accession NZ_CP097790
Organism Pasteurella multocida strain 31971

Toxin (Protein)


Gene name hipA Uniprot ID V4NI19
Locus tag M9415_RS02465 Protein ID WP_005752891.1
Coordinates 506663..507970 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V4NAB0
Locus tag M9415_RS02470 Protein ID WP_005752888.1
Coordinates 507972..508307 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9415_RS02455 (M9415_02455) 502661..505243 + 2583 WP_046333525.1 DNA mismatch repair protein MutS -
M9415_RS02460 (M9415_02460) 505309..506445 - 1137 WP_080940661.1 anhydro-N-acetylmuramic acid kinase -
M9415_RS02465 (M9415_02465) 506663..507970 + 1308 WP_005752891.1 HipA domain-containing protein Toxin
M9415_RS02470 (M9415_02470) 507972..508307 + 336 WP_005752888.1 helix-turn-helix transcriptional regulator Antitoxin
M9415_RS02475 (M9415_02475) 508403..509071 - 669 WP_005724847.1 NAD(P)H-dependent oxidoreductase -
M9415_RS02480 (M9415_02480) 509112..510479 - 1368 WP_046333523.1 oxygen-independent coproporphyrinogen III oxidase -
M9415_RS02485 (M9415_02485) 510503..510931 - 429 WP_005719208.1 DUF2489 domain-containing protein -
M9415_RS02490 (M9415_02490) 510937..511506 - 570 WP_005755466.1 Der GTPase-activating protein YihI -
M9415_RS02495 (M9415_02495) 511570..512229 - 660 WP_005724855.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-375)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50526.31 Da        Isoelectric Point: 4.9118

>T246236 WP_005752891.1 NZ_CP097790:506663-507970 [Pasteurella multocida]
MEKLTLQIYLEQAWCDLAFLYFDSETYQLCNFEYLTDYVVQHYGKTGEHAVSLNYPVNVFIDDTTSLWSWLSDIAPAGAS
RRYWLEALDIKQESEEKQQFLLLKHAAISPIGNLRIKDAVPEQVEVRLFDLDKAKDRQSDFLEYVNQSGAMVGGATGAGG
EAPKLLLKRRENQVWIDNQQQGQDQDVSYLVKYPRGNYSPIDCDILRAEYHYYQELAQLGFDTIDTTRMRLEEGKRYPSL
WLPRFDIVQREGKTHRLAFESVYSLLQKQGGVLDHETTLRQLIERISTARLQFAQTDFVIEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQRIWLAPIYDFAPMRADPEGIIRTTTWQTKGEYPQEFAGEYHFERIAEVLADLVEPTLLMQELRRLAGSLVD
LKSRLVQRNLPQSILDFPAIGFDYLPEKLKKWGLI

Download         Length: 1308 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12520.60 Da        Isoelectric Point: 10.5259

>AT246236 WP_005752888.1 NZ_CP097790:507972-508307 [Pasteurella multocida]
MQITRRNASTKGASVAEIDRKKVRNEIIQAMLMGELSQGEALRKLRIEMFGINQQHYIQLVKVSRQTLSNIENDKGNYSV
ETINKVFKPFGLELGLVPVSKALLKELFSTA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V4NI19

Antitoxin

Source ID Structure
AlphaFold DB V4NAB0

References