246235

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1137953..1138870 Replicon chromosome
Accession NZ_CP097784
Organism Bacillus velezensis strain V 3.14

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag MF619_RS06190 Protein ID WP_025851786.1
Coordinates 1138124..1138870 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag MF619_RS06185 Protein ID WP_003154807.1
Coordinates 1137953..1138123 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF619_RS06145 (MF619_001229) 1133184..1134806 + 1623 WP_003154821.1 pyocin knob domain-containing protein -
MF619_RS06150 (MF619_001230) 1134819..1135190 + 372 WP_003154820.1 XkdW family protein -
MF619_RS06155 (MF619_001231) 1135196..1135393 + 198 WP_003154819.1 XkdX family protein -
MF619_RS06160 (MF619_001232) 1135450..1136211 + 762 WP_025851792.1 hypothetical protein -
MF619_RS06165 (MF619_001233) 1136263..1136526 + 264 WP_003154815.1 hemolysin XhlA family protein -
MF619_RS06170 (MF619_001234) 1136540..1136803 + 264 WP_025851790.1 phage holin -
MF619_RS06175 (MF619_001235) 1136817..1137695 + 879 WP_025851788.1 N-acetylmuramoyl-L-alanine amidase -
MF619_RS06180 (MF619_001236) 1137731..1137856 - 126 WP_003154809.1 hypothetical protein -
MF619_RS06185 (MF619_001237) 1137953..1138123 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
MF619_RS06190 (MF619_001238) 1138124..1138870 - 747 WP_025851786.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
MF619_RS06195 (MF619_001239) 1138975..1139973 - 999 WP_003154805.1 inorganic phosphate transporter -
MF619_RS06200 (MF619_001240) 1139986..1140603 - 618 WP_003154804.1 DUF47 domain-containing protein -
MF619_RS06205 (MF619_001241) 1140889..1142205 - 1317 WP_003154801.1 amino acid permease -
MF619_RS06210 (MF619_001242) 1142528..1143478 + 951 WP_015388352.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29048.53 Da        Isoelectric Point: 4.7003

>T246235 WP_025851786.1 NZ_CP097784:c1138870-1138124 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CEYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT246235 WP_003154807.1 NZ_CP097784:c1138123-1137953 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References