Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1067667..1068584 Replicon chromosome
Accession NZ_CP097779
Organism Bacillus velezensis strain R 4.6

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag MF621_RS05555 Protein ID WP_025851786.1
Coordinates 1067838..1068584 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag MF621_RS05550 Protein ID WP_003154807.1
Coordinates 1067667..1067837 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF621_RS05510 (MF621_001101) 1062898..1064520 + 1623 WP_003154821.1 pyocin knob domain-containing protein -
MF621_RS05515 (MF621_001102) 1064533..1064904 + 372 WP_003154820.1 XkdW family protein -
MF621_RS05520 (MF621_001103) 1064910..1065107 + 198 WP_003154819.1 XkdX family protein -
MF621_RS05525 (MF621_001104) 1065164..1065925 + 762 WP_025851792.1 hypothetical protein -
MF621_RS05530 (MF621_001105) 1065977..1066240 + 264 WP_003154815.1 hemolysin XhlA family protein -
MF621_RS05535 (MF621_001106) 1066254..1066517 + 264 WP_025851790.1 phage holin -
MF621_RS05540 (MF621_001107) 1066531..1067409 + 879 WP_025851788.1 N-acetylmuramoyl-L-alanine amidase -
MF621_RS05545 (MF621_001108) 1067445..1067570 - 126 WP_003154809.1 hypothetical protein -
MF621_RS05550 (MF621_001109) 1067667..1067837 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
MF621_RS05555 (MF621_001110) 1067838..1068584 - 747 WP_025851786.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
MF621_RS05560 (MF621_001111) 1068689..1069687 - 999 WP_003154805.1 inorganic phosphate transporter -
MF621_RS05565 (MF621_001112) 1069700..1070317 - 618 WP_003154804.1 DUF47 domain-containing protein -
MF621_RS05570 (MF621_001113) 1070603..1071919 - 1317 WP_003154801.1 amino acid permease -
MF621_RS05575 (MF621_001114) 1072242..1073192 + 951 WP_015388352.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29048.53 Da        Isoelectric Point: 4.7003

>T246233 WP_025851786.1 NZ_CP097779:c1068584-1067838 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CEYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT246233 WP_003154807.1 NZ_CP097779:c1067837-1067667 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References