Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 1459371..1460009 Replicon chromosome
Accession NZ_CP097778
Organism Paenibacillus polymyxa strain K 1.14

Toxin (Protein)


Gene name pemK Uniprot ID H6CFY1
Locus tag MF622_RS06735 Protein ID WP_007429335.1
Coordinates 1459659..1460009 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H6CFY0
Locus tag MF622_RS06730 Protein ID WP_007429334.1
Coordinates 1459371..1459652 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF622_RS06715 (MF622_001339) 1455872..1456018 - 147 WP_250243792.1 hypothetical protein -
MF622_RS06720 (MF622_001340) 1456335..1457612 + 1278 WP_250243794.1 DUF4367 domain-containing protein -
MF622_RS06725 (MF622_001341) 1457881..1459077 + 1197 WP_250243797.1 alanine racemase -
MF622_RS06730 (MF622_001342) 1459371..1459652 + 282 WP_007429334.1 ribbon-helix-helix protein, CopG family Antitoxin
MF622_RS06735 (MF622_001343) 1459659..1460009 + 351 WP_007429335.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MF622_RS06740 (MF622_001344) 1460189..1462411 + 2223 WP_250245180.1 Tex family protein -
MF622_RS06745 (MF622_001345) 1462517..1462651 - 135 WP_007429337.1 cortex morphogenetic protein CmpA -
MF622_RS06750 (MF622_001346) 1462796..1463320 + 525 WP_250243800.1 SprT family protein -
MF622_RS06765 (MF622_001349) 1463709..1464584 - 876 WP_250243802.1 Cof-type HAD-IIB family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12822.77 Da        Isoelectric Point: 5.6195

>T246231 WP_007429335.1 NZ_CP097778:1459659-1460009 [Paenibacillus polymyxa]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAATHGFDRDSVVLLEQI
RTIDKQRLTDKITHLDEETMRKVSDSLQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10636.25 Da        Isoelectric Point: 8.5257

>AT246231 WP_007429334.1 NZ_CP097778:1459371-1459652 [Paenibacillus polymyxa]
MANLQNTKRIMISLPDHLLQEVDGIVAMENSNRSEFIRQAMKLYVGERKKRYIREAMQRGYMEMAKINLTMASEAFHAEE
DANSTLGRTVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H6CFY1

Antitoxin

Source ID Structure
AlphaFold DB H6CFY0

References