Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 4477681..4478319 Replicon chromosome
Accession NZ_CP097775
Organism Paenibacillus polymyxa strain O 1.27

Toxin (Protein)


Gene name pemK Uniprot ID H6CFY1
Locus tag MF623_RS19620 Protein ID WP_007429335.1
Coordinates 4477969..4478319 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H6CFY0
Locus tag MF623_RS19615 Protein ID WP_007429334.1
Coordinates 4477681..4477962 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF623_RS19595 (MF623_003907) 4472697..4473668 - 972 WP_107733997.1 ABC transporter substrate-binding protein -
MF623_RS19600 (MF623_003908) 4473903..4474535 + 633 WP_016821167.1 LysE family transporter -
MF623_RS19605 (MF623_003909) 4474646..4475923 + 1278 WP_017426524.1 outer membrane lipoprotein-sorting protein -
MF623_RS19610 (MF623_003910) 4476191..4477387 + 1197 WP_026065391.1 alanine racemase -
MF623_RS19615 (MF623_003911) 4477681..4477962 + 282 WP_007429334.1 ribbon-helix-helix protein, CopG family Antitoxin
MF623_RS19620 (MF623_003912) 4477969..4478319 + 351 WP_007429335.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MF623_RS19625 (MF623_003913) 4478498..4480720 + 2223 WP_017426526.1 Tex family protein -
MF623_RS19630 (MF623_003914) 4480824..4480958 - 135 WP_016821163.1 cortex morphogenetic protein CmpA -
MF623_RS19635 (MF623_003915) 4481101..4481613 + 513 WP_016821162.1 SprT family protein -
MF623_RS19650 (MF623_003918) 4481992..4482867 - 876 WP_017426527.1 Cof-type HAD-IIB family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12822.77 Da        Isoelectric Point: 5.6195

>T246230 WP_007429335.1 NZ_CP097775:4477969-4478319 [Paenibacillus polymyxa]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAATHGFDRDSVVLLEQI
RTIDKQRLTDKITHLDEETMRKVSDSLQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10636.25 Da        Isoelectric Point: 8.5257

>AT246230 WP_007429334.1 NZ_CP097775:4477681-4477962 [Paenibacillus polymyxa]
MANLQNTKRIMISLPDHLLQEVDGIVAMENSNRSEFIRQAMKLYVGERKKRYIREAMQRGYMEMAKINLTMASEAFHAEE
DANSTLGRTVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H6CFY1

Antitoxin

Source ID Structure
AlphaFold DB H6CFY0

References