246210

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4204375..4205189 Replicon chromosome
Accession NZ_CP097726
Organism Escherichia coli strain MS1050

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag M9O78_RS19930 Protein ID WP_001054376.1
Coordinates 4204375..4204632 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag M9O78_RS19935 Protein ID WP_001309181.1
Coordinates 4204644..4205189 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O78_RS19905 (4199663) 4199663..4200769 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
M9O78_RS19910 (4200834) 4200834..4201814 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
M9O78_RS19915 (4201924) 4201924..4202129 + 206 Protein_3899 HNH endonuclease -
M9O78_RS19920 (4202397) 4202397..4203637 - 1241 Protein_3900 helicase YjhR -
M9O78_RS19925 (4203753) 4203753..4203884 + 132 WP_001309182.1 hypothetical protein -
M9O78_RS19930 (4204375) 4204375..4204632 + 258 WP_001054376.1 YjhX family toxin Toxin
M9O78_RS19935 (4204644) 4204644..4205189 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
M9O78_RS19940 (4205245) 4205245..4205991 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
M9O78_RS19945 (4206160) 4206160..4206378 + 219 Protein_3905 hypothetical protein -
M9O78_RS19950 (4206416) 4206416..4206532 + 117 Protein_3906 VOC family protein -
M9O78_RS19955 (4206777) 4206777..4207898 + 1122 WP_000010829.1 M42 family metallopeptidase -
M9O78_RS19960 (4207895) 4207895..4208173 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
M9O78_RS19965 (4208185) 4208185..4209498 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4196869..4213413 16544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T246210 WP_001054376.1 NZ_CP097726:4204375-4204632 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT246210 WP_001309181.1 NZ_CP097726:4204644-4205189 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References