Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3599452..3600070 Replicon chromosome
Accession NZ_CP097726
Organism Escherichia coli strain MS1050

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M9O78_RS17125 Protein ID WP_001291435.1
Coordinates 3599852..3600070 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M9O78_RS17120 Protein ID WP_000344800.1
Coordinates 3599452..3599826 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O78_RS17110 (3594541) 3594541..3595734 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M9O78_RS17115 (3595757) 3595757..3598906 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
M9O78_RS17120 (3599452) 3599452..3599826 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M9O78_RS17125 (3599852) 3599852..3600070 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M9O78_RS17130 (3600242) 3600242..3600793 + 552 WP_000102559.1 maltose O-acetyltransferase -
M9O78_RS17135 (3600909) 3600909..3601379 + 471 WP_000136192.1 YlaC family protein -
M9O78_RS17140 (3601543) 3601543..3603093 + 1551 WP_001389864.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M9O78_RS17145 (3603135) 3603135..3603488 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M9O78_RS17155 (3603867) 3603867..3604178 + 312 WP_000409911.1 MGMT family protein -
M9O78_RS17160 (3604209) 3604209..3604781 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246208 WP_001291435.1 NZ_CP097726:3599852-3600070 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246208 WP_000344800.1 NZ_CP097726:3599452-3599826 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References