246207

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3150769..3151474 Replicon chromosome
Accession NZ_CP097726
Organism Escherichia coli strain MS1050

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag M9O78_RS15025 Protein ID WP_000539521.1
Coordinates 3150769..3151155 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M9O78_RS15030 Protein ID WP_001280945.1
Coordinates 3151145..3151474 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O78_RS15005 (3146773) 3146773..3147399 + 627 WP_001295292.1 glutathione S-transferase GstB -
M9O78_RS15010 (3147396) 3147396..3148511 - 1116 WP_000555038.1 aldose sugar dehydrogenase YliI -
M9O78_RS15015 (3148622) 3148622..3149005 - 384 WP_000497137.1 biofilm formation regulator BssR -
M9O78_RS15020 (3149218) 3149218..3150543 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
M9O78_RS15025 (3150769) 3150769..3151155 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9O78_RS15030 (3151145) 3151145..3151474 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
M9O78_RS15035 (3151544) 3151544..3152872 - 1329 WP_000086879.1 GGDEF domain-containing protein -
M9O78_RS15040 (3152880) 3152880..3155228 - 2349 WP_001322378.1 EAL domain-containing protein -
M9O78_RS15045 (3155406) 3155406..3156317 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T246207 WP_000539521.1 NZ_CP097726:3150769-3151155 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT246207 WP_001280945.1 NZ_CP097726:3151145-3151474 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References