Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2603567..2604205 Replicon chromosome
Accession NZ_CP097726
Organism Escherichia coli strain MS1050

Toxin (Protein)


Gene name hicA Uniprot ID B7N4J4
Locus tag M9O78_RS12385 Protein ID WP_000813797.1
Coordinates 2604029..2604205 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M9O78_RS12380 Protein ID WP_076611057.1
Coordinates 2603567..2603983 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O78_RS12360 (2598719) 2598719..2599660 - 942 WP_001251335.1 ABC transporter permease -
M9O78_RS12365 (2599661) 2599661..2600674 - 1014 WP_000220413.1 ABC transporter ATP-binding protein -
M9O78_RS12370 (2600692) 2600692..2601837 - 1146 WP_000047447.1 ABC transporter substrate-binding protein -
M9O78_RS12375 (2602082) 2602082..2603488 - 1407 WP_000760613.1 PLP-dependent aminotransferase family protein -
M9O78_RS12380 (2603567) 2603567..2603983 - 417 WP_076611057.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M9O78_RS12385 (2604029) 2604029..2604205 - 177 WP_000813797.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M9O78_RS12390 (2604427) 2604427..2604657 + 231 WP_000494244.1 YncJ family protein -
M9O78_RS12395 (2604749) 2604749..2606710 - 1962 WP_001309488.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M9O78_RS12400 (2606783) 2606783..2607319 - 537 WP_000429161.1 DNA-binding transcriptional regulator SutR -
M9O78_RS12405 (2607411) 2607411..2608583 + 1173 WP_001236223.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.76 Da        Isoelectric Point: 11.5666

>T246205 WP_000813797.1 NZ_CP097726:c2604205-2604029 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15251.65 Da        Isoelectric Point: 4.5908

>AT246205 WP_076611057.1 NZ_CP097726:c2603983-2603567 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J715

Antitoxin

Source ID Structure

References