Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 968909..969563 Replicon chromosome
Accession NZ_CP097726
Organism Escherichia coli strain MS1050

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag M9O78_RS04665 Protein ID WP_000244765.1
Coordinates 969156..969563 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M9O78_RS04660 Protein ID WP_000354046.1
Coordinates 968909..969175 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O78_RS04640 (964997) 964997..966430 - 1434 WP_063082439.1 6-phospho-beta-glucosidase BglA -
M9O78_RS04645 (966475) 966475..966786 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
M9O78_RS04650 (966950) 966950..967609 + 660 WP_000250274.1 hemolysin III family protein -
M9O78_RS04655 (967686) 967686..968666 - 981 WP_049038218.1 tRNA-modifying protein YgfZ -
M9O78_RS04660 (968909) 968909..969175 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M9O78_RS04665 (969156) 969156..969563 + 408 WP_000244765.1 protein YgfX Toxin
M9O78_RS04670 (969603) 969603..970124 - 522 WP_001055874.1 flavodoxin FldB -
M9O78_RS04675 (970236) 970236..971132 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M9O78_RS04680 (971157) 971157..971867 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M9O78_RS04685 (971873) 971873..973606 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T246197 WP_000244765.1 NZ_CP097726:969156-969563 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT246197 WP_000354046.1 NZ_CP097726:968909-969175 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References