Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4282264..4282761 Replicon chromosome
Accession NZ_CP097724
Organism Escherichia coli strain MS1494

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag M9O75_RS20840 Protein ID WP_001173343.1
Coordinates 4282264..4282437 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag M9O75_RS20845 Protein ID WP_001312331.1
Coordinates 4282465..4282761 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O75_RS20830 (4278934) 4278934..4280391 + 1458 WP_000856828.1 dipeptide/tripeptide permease DtpC -
M9O75_RS20835 (4280628) 4280628..4282145 + 1518 WP_000003805.1 lysine--tRNA ligase -
M9O75_RS20840 (4282264) 4282264..4282437 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
M9O75_RS20845 (4282465) 4282465..4282761 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
M9O75_RS20850 (4282990) 4282990..4283262 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
M9O75_RS20855 (4283274) 4283274..4283504 - 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
M9O75_RS20860 (4283685) 4283685..4285316 + 1632 WP_001216466.1 sensor histidine kinase -
M9O75_RS20865 (4285313) 4285313..4286032 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T246190 WP_001173343.1 NZ_CP097724:c4282437-4282264 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT246190 WP_001312331.1 NZ_CP097724:c4282761-4282465 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References