Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3438156..3438774 Replicon chromosome
Accession NZ_CP097724
Organism Escherichia coli strain MS1494

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M9O75_RS16685 Protein ID WP_001291435.1
Coordinates 3438556..3438774 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M9O75_RS16680 Protein ID WP_000344800.1
Coordinates 3438156..3438530 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O75_RS16670 (3433246) 3433246..3434439 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M9O75_RS16675 (3434462) 3434462..3437611 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M9O75_RS16680 (3438156) 3438156..3438530 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M9O75_RS16685 (3438556) 3438556..3438774 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M9O75_RS16690 (3438947) 3438947..3439498 + 552 WP_000102539.1 maltose O-acetyltransferase -
M9O75_RS16695 (3439614) 3439614..3440084 + 471 WP_000136192.1 YlaC family protein -
M9O75_RS16700 (3440248) 3440248..3441798 + 1551 WP_001468081.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M9O75_RS16705 (3441840) 3441840..3442193 - 354 WP_000878142.1 DUF1428 family protein -
M9O75_RS16715 (3442572) 3442572..3442883 + 312 WP_000409908.1 MGMT family protein -
M9O75_RS16720 (3442914) 3442914..3443486 - 573 WP_000779844.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246186 WP_001291435.1 NZ_CP097724:3438556-3438774 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246186 WP_000344800.1 NZ_CP097724:3438156-3438530 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References