Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4132233..4132828 Replicon chromosome
Accession NZ_CP097721
Organism Escherichia coli strain MS1665

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M9O79_RS19835 Protein ID WP_000239579.1
Coordinates 4132233..4132583 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M9O79_RS19840 Protein ID WP_001223208.1
Coordinates 4132577..4132828 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O79_RS19815 (4127509) 4127509..4128531 - 1023 WP_001296689.1 ABC transporter permease -
M9O79_RS19820 (4128545) 4128545..4130047 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
M9O79_RS19825 (4130357) 4130357..4131313 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M9O79_RS19830 (4131623) 4131623..4132153 + 531 WP_000055072.1 inorganic diphosphatase -
M9O79_RS19835 (4132233) 4132233..4132583 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M9O79_RS19840 (4132577) 4132577..4132828 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M9O79_RS19845 (4133041) 4133041..4133382 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M9O79_RS19850 (4133385) 4133385..4137164 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T246167 WP_000239579.1 NZ_CP097721:c4132583-4132233 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT246167 WP_001223208.1 NZ_CP097721:c4132828-4132577 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References