Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3414387..3415005 Replicon chromosome
Accession NZ_CP097721
Organism Escherichia coli strain MS1665

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M9O79_RS16455 Protein ID WP_001291435.1
Coordinates 3414787..3415005 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M9O79_RS16450 Protein ID WP_000344800.1
Coordinates 3414387..3414761 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O79_RS16440 (3409476) 3409476..3410669 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M9O79_RS16445 (3410692) 3410692..3413841 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M9O79_RS16450 (3414387) 3414387..3414761 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M9O79_RS16455 (3414787) 3414787..3415005 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M9O79_RS16460 (3415177) 3415177..3415728 + 552 WP_000102564.1 maltose O-acetyltransferase -
M9O79_RS16465 (3415844) 3415844..3416314 + 471 WP_000136192.1 YlaC family protein -
M9O79_RS16470 (3416478) 3416478..3418028 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M9O79_RS16475 (3418070) 3418070..3418423 - 354 WP_000878141.1 DUF1428 family protein -
M9O79_RS16485 (3418802) 3418802..3419113 + 312 WP_000409911.1 MGMT family protein -
M9O79_RS16490 (3419144) 3419144..3419716 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246162 WP_001291435.1 NZ_CP097721:3414787-3415005 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246162 WP_000344800.1 NZ_CP097721:3414387-3414761 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References