Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2440383..2441021 Replicon chromosome
Accession NZ_CP097721
Organism Escherichia coli strain MS1665

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag M9O79_RS11860 Protein ID WP_000813794.1
Coordinates 2440845..2441021 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M9O79_RS11855 Protein ID WP_001270286.1
Coordinates 2440383..2440799 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O79_RS11835 (2435535) 2435535..2436476 - 942 WP_001251315.1 ABC transporter permease -
M9O79_RS11840 (2436477) 2436477..2437490 - 1014 WP_000220416.1 ABC transporter ATP-binding protein -
M9O79_RS11845 (2437508) 2437508..2438653 - 1146 WP_000047455.1 ABC transporter substrate-binding protein -
M9O79_RS11850 (2438898) 2438898..2440304 - 1407 WP_000760589.1 PLP-dependent aminotransferase family protein -
M9O79_RS11855 (2440383) 2440383..2440799 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M9O79_RS11860 (2440845) 2440845..2441021 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M9O79_RS11865 (2441243) 2441243..2441473 + 231 WP_000494244.1 YncJ family protein -
M9O79_RS11870 (2441565) 2441565..2443526 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M9O79_RS11875 (2443599) 2443599..2444135 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
M9O79_RS11880 (2444227) 2444227..2445402 + 1176 WP_001236258.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2445442..2446707 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T246161 WP_000813794.1 NZ_CP097721:c2441021-2440845 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT246161 WP_001270286.1 NZ_CP097721:c2440799-2440383 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References