Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1360955..1361580 Replicon chromosome
Accession NZ_CP097721
Organism Escherichia coli strain MS1665

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag M9O79_RS06635 Protein ID WP_000911329.1
Coordinates 1361182..1361580 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag M9O79_RS06630 Protein ID WP_000450524.1
Coordinates 1360955..1361182 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O79_RS06605 (1356756) 1356756..1357226 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
M9O79_RS06610 (1357226) 1357226..1357798 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
M9O79_RS06615 (1357944) 1357944..1358822 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
M9O79_RS06620 (1358839) 1358839..1359873 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
M9O79_RS06625 (1360086) 1360086..1360799 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
M9O79_RS06630 (1360955) 1360955..1361182 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
M9O79_RS06635 (1361182) 1361182..1361580 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
M9O79_RS06640 (1361727) 1361727..1362590 + 864 WP_001267507.1 neutral zinc metallopeptidase -
M9O79_RS06645 (1362605) 1362605..1364620 + 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
M9O79_RS06650 (1364694) 1364694..1365392 + 699 WP_000679812.1 esterase -
M9O79_RS06655 (1365502) 1365502..1365702 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T246153 WP_000911329.1 NZ_CP097721:1361182-1361580 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT246153 WP_000450524.1 NZ_CP097721:1360955-1361182 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References