Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 871068..871722 Replicon chromosome
Accession NZ_CP097721
Organism Escherichia coli strain MS1665

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag M9O79_RS04250 Protein ID WP_000244772.1
Coordinates 871315..871722 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M9O79_RS04245 Protein ID WP_000354046.1
Coordinates 871068..871334 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O79_RS04220 (866356) 866356..867099 + 744 WP_000951940.1 SDR family oxidoreductase -
M9O79_RS04225 (867156) 867156..868589 - 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
M9O79_RS04230 (868634) 868634..868945 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
M9O79_RS04235 (869109) 869109..869768 + 660 WP_000250274.1 hemolysin III family protein -
M9O79_RS04240 (869845) 869845..870825 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
M9O79_RS04245 (871068) 871068..871334 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M9O79_RS04250 (871315) 871315..871722 + 408 WP_000244772.1 protein YgfX Toxin
M9O79_RS04255 (871762) 871762..872283 - 522 WP_001055874.1 flavodoxin FldB -
M9O79_RS04260 (872395) 872395..873291 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M9O79_RS04265 (873316) 873316..874026 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M9O79_RS04270 (874032) 874032..875765 + 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T246151 WP_000244772.1 NZ_CP097721:871315-871722 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT246151 WP_000354046.1 NZ_CP097721:871068-871334 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References