Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 106494..107119 Replicon plasmid pMS1679-1
Accession NZ_CP097720
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M9O74_RS25940 Protein ID WP_000911333.1
Coordinates 106494..106892 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag M9O74_RS25945 Protein ID WP_000450520.1
Coordinates 106892..107119 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS25920 (101746) 101746..103318 - 1573 Protein_107 IS66-like element ISCro1 family transposase -
M9O74_RS25925 (103338) 103338..103685 - 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
M9O74_RS25930 (103685) 103685..104362 - 678 WP_001682408.1 IS66-like element accessory protein TnpA -
M9O74_RS25935 (104416) 104416..106485 + 2070 Protein_110 type IV conjugative transfer system coupling protein TraD -
M9O74_RS25940 (106494) 106494..106892 - 399 WP_000911333.1 tRNA(fMet)-specific endonuclease VapC Toxin
M9O74_RS25945 (106892) 106892..107119 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iucA / iucB / iucC / iucD / iutA / vat / iroN / iroE / iroD / iroC / iroB 1..201944 201944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14919.19 Da        Isoelectric Point: 7.8605

>T246148 WP_000911333.1 NZ_CP097720:c106892-106494 [Escherichia coli]
MLKFMLDTNICIFTMKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT246148 WP_000450520.1 NZ_CP097720:c107119-106892 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References