Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4733522..4734447 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag M9O74_RS23295 Protein ID WP_014640052.1
Coordinates 4733522..4733908 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag M9O74_RS23300 Protein ID WP_024174200.1
Coordinates 4733938..4734447 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS23250 (4728968) 4728968..4729278 + 311 Protein_4561 hypothetical protein -
M9O74_RS23255 (4729293) 4729293..4729655 + 363 WP_000135680.1 protein YfdP -
M9O74_RS23260 (4729721) 4729721..4730545 + 825 WP_000081280.1 DUF2303 family protein -
M9O74_RS23265 (4730673) 4730673..4731209 + 537 WP_028125940.1 5'-deoxynucleotidase -
M9O74_RS23270 (4731200) 4731200..4731562 + 363 WP_028125941.1 phage protein -
M9O74_RS23275 (4731562) 4731562..4732371 + 810 WP_000206745.1 hypothetical protein -
M9O74_RS23280 (4732371) 4732371..4732943 + 573 Protein_4567 3'-5' exoribonuclease -
M9O74_RS23285 (4732980) 4732980..4733261 + 282 WP_001093917.1 pyocin activator PrtN family protein -
M9O74_RS23290 (4733309) 4733309..4733482 - 174 WP_000390072.1 hypothetical protein -
M9O74_RS23295 (4733522) 4733522..4733908 - 387 WP_014640052.1 hypothetical protein Toxin
M9O74_RS23300 (4733938) 4733938..4734447 - 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
M9O74_RS23305 (4734982) 4734982..4735497 + 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
M9O74_RS23310 (4735539) 4735539..4735748 - 210 WP_001296638.1 CsbD family protein -
M9O74_RS23315 (4735864) 4735864..4737189 - 1326 WP_001318177.1 MATE family efflux transporter DinF -
M9O74_RS23320 (4737262) 4737262..4737870 - 609 WP_000646078.1 transcriptional repressor LexA -
M9O74_RS23325 (4737980) 4737980..4738348 - 369 WP_000002907.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4696134..4737870 41736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T246140 WP_014640052.1 NZ_CP097719:c4733908-4733522 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT246140 WP_024174200.1 NZ_CP097719:c4734447-4733938 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References