Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4606903..4607400 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag M9O74_RS22590 Protein ID WP_001173343.1
Coordinates 4606903..4607076 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A1V2FLJ5
Locus tag M9O74_RS22595 Protein ID WP_001317561.1
Coordinates 4607104..4607400 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS22580 (4603573) 4603573..4605030 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
M9O74_RS22585 (4605267) 4605267..4606784 + 1518 WP_000003805.1 lysine--tRNA ligase -
M9O74_RS22590 (4606903) 4606903..4607076 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
M9O74_RS22595 (4607104) 4607104..4607400 - 297 WP_001317561.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
M9O74_RS22600 (4607627) 4607627..4607899 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
M9O74_RS22605 (4607911) 4607911..4608141 - 231 WP_000371717.1 4Fe-4S mono-cluster protein YjdI -
M9O74_RS22610 (4608321) 4608321..4609952 + 1632 WP_001216477.1 sensor histidine kinase -
M9O74_RS22615 (4609949) 4609949..4610668 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T246139 WP_001173343.1 NZ_CP097719:c4607076-4606903 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT246139 WP_001317561.1 NZ_CP097719:c4607400-4607104 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMSFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2FLJ5

References