Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4595119..4595954 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag M9O74_RS22545 Protein ID WP_267323347.1
Coordinates 4595577..4595954 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4TIK7
Locus tag M9O74_RS22540 Protein ID WP_001285605.1
Coordinates 4595119..4595487 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS22500 4590667..4591551 + 885 WP_186212692.1 50S ribosome-binding GTPase -
M9O74_RS22505 4591670..4592347 + 678 WP_001097368.1 hypothetical protein -
M9O74_RS22510 4592353..4592586 + 234 WP_001278287.1 DUF905 family protein -
M9O74_RS22515 4592676..4593494 + 819 WP_001175153.1 DUF932 domain-containing protein -
M9O74_RS22520 4593520..4593660 - 141 WP_000997937.1 hypothetical protein -
M9O74_RS22525 4593760..4594239 + 480 WP_001696591.1 antirestriction protein -
M9O74_RS22530 4594255..4594731 + 477 WP_001696592.1 RadC family protein -
M9O74_RS22535 4594818..4595039 + 222 Protein_4418 DUF987 domain-containing protein -
M9O74_RS22540 4595119..4595487 + 369 WP_001285605.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M9O74_RS22545 4595577..4595954 + 378 WP_267323347.1 TA system toxin CbtA family protein Toxin
M9O74_RS22550 4595951..4596100 + 150 Protein_4421 DUF5983 family protein -
M9O74_RS22555 4596176..4596373 + 198 WP_086795284.1 DUF957 domain-containing protein -
M9O74_RS22560 4596458..4597300 + 843 WP_001290171.1 DUF4942 domain-containing protein -
M9O74_RS22565 4598049..4599587 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13981.99 Da        Isoelectric Point: 7.7551

>T246138 WP_267323347.1 NZ_CP097719:4595577-4595954 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHHGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.48 Da        Isoelectric Point: 6.0601

>AT246138 WP_001285605.1 NZ_CP097719:4595119-4595487 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2V3N6

References