Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3731703..3732321 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M9O74_RS18435 Protein ID WP_001291435.1
Coordinates 3732103..3732321 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M9O74_RS18430 Protein ID WP_000344800.1
Coordinates 3731703..3732077 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS18420 (3726792) 3726792..3727985 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M9O74_RS18425 (3728008) 3728008..3731157 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M9O74_RS18430 (3731703) 3731703..3732077 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M9O74_RS18435 (3732103) 3732103..3732321 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M9O74_RS18440 (3732493) 3732493..3733044 + 552 WP_000102564.1 maltose O-acetyltransferase -
M9O74_RS18445 (3733160) 3733160..3733630 + 471 WP_000136192.1 YlaC family protein -
M9O74_RS18450 (3733794) 3733794..3735344 + 1551 WP_001317659.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M9O74_RS18455 (3735386) 3735386..3735739 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M9O74_RS18465 (3736118) 3736118..3736429 + 312 WP_000409911.1 MGMT family protein -
M9O74_RS18470 (3736460) 3736460..3737032 - 573 WP_000779821.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246136 WP_001291435.1 NZ_CP097719:3732103-3732321 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246136 WP_000344800.1 NZ_CP097719:3731703-3732077 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References