Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3315122..3315827 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag M9O74_RS16295 Protein ID WP_000539521.1
Coordinates 3315122..3315508 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M9O74_RS16300 Protein ID WP_001280945.1
Coordinates 3315498..3315827 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS16275 (3311126) 3311126..3311752 + 627 WP_001295292.1 glutathione S-transferase GstB -
M9O74_RS16280 (3311749) 3311749..3312864 - 1116 WP_000555041.1 aldose sugar dehydrogenase YliI -
M9O74_RS16285 (3312975) 3312975..3313358 - 384 WP_000497137.1 biofilm formation regulator BssR -
M9O74_RS16290 (3313571) 3313571..3314896 + 1326 WP_000049378.1 30S ribosomal protein S12 methylthiotransferase RimO -
M9O74_RS16295 (3315122) 3315122..3315508 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9O74_RS16300 (3315498) 3315498..3315827 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
M9O74_RS16305 (3315897) 3315897..3317225 - 1329 WP_000086919.1 GGDEF domain-containing protein -
M9O74_RS16310 (3317233) 3317233..3319581 - 2349 Protein_3202 EAL domain-containing protein -
M9O74_RS16315 (3319759) 3319759..3320670 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T246134 WP_000539521.1 NZ_CP097719:3315122-3315508 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT246134 WP_001280945.1 NZ_CP097719:3315498-3315827 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References