Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3067761..3068545 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag M9O74_RS15110 Protein ID WP_000613624.1
Coordinates 3068051..3068545 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B1LI61
Locus tag M9O74_RS15105 Protein ID WP_001110446.1
Coordinates 3067761..3068054 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS15095 (3062910) 3062910..3063869 - 960 WP_000846329.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
M9O74_RS15100 (3064442) 3064442..3067627 + 3186 WP_000827395.1 ribonuclease E -
M9O74_RS15105 (3067761) 3067761..3068054 + 294 WP_001110446.1 DUF1778 domain-containing protein Antitoxin
M9O74_RS15110 (3068051) 3068051..3068545 + 495 WP_000613624.1 GNAT family N-acetyltransferase Toxin
M9O74_RS15115 (3068640) 3068640..3069593 - 954 WP_001212762.1 flagellar hook-associated protein FlgL -
M9O74_RS15120 (3069605) 3069605..3071248 - 1644 WP_260838220.1 flagellar hook-associated protein FlgK -
M9O74_RS15125 (3071314) 3071314..3072255 - 942 WP_001317765.1 flagellar assembly peptidoglycan hydrolase FlgJ -
M9O74_RS15130 (3072255) 3072255..3073352 - 1098 WP_000589326.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18142.04 Da        Isoelectric Point: 7.7444

>T246133 WP_000613624.1 NZ_CP097719:3068051-3068545 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIDRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11079.67 Da        Isoelectric Point: 10.5423

>AT246133 WP_001110446.1 NZ_CP097719:3067761-3068054 [Escherichia coli]
MPAANNIPARRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829G775

References