Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2653244..2653880 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name hicA Uniprot ID A0A5F1EUB3
Locus tag M9O74_RS12925 Protein ID WP_000813796.1
Coordinates 2653704..2653880 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M9O74_RS12920 Protein ID WP_076838470.1
Coordinates 2653244..2653660 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS12900 (2648396) 2648396..2649337 - 942 WP_001251307.1 ABC transporter permease -
M9O74_RS12905 (2649338) 2649338..2650351 - 1014 WP_000220433.1 ABC transporter ATP-binding protein -
M9O74_RS12910 (2650369) 2650369..2651514 - 1146 WP_000047448.1 ABC transporter substrate-binding protein -
M9O74_RS12915 (2651759) 2651759..2653165 - 1407 WP_000760605.1 PLP-dependent aminotransferase family protein -
M9O74_RS12920 (2653244) 2653244..2653660 - 417 WP_076838470.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M9O74_RS12925 (2653704) 2653704..2653880 - 177 WP_000813796.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M9O74_RS12930 (2654102) 2654102..2654332 + 231 WP_000494243.1 YncJ family protein -
M9O74_RS12935 (2654424) 2654424..2656385 - 1962 WP_001317809.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M9O74_RS12940 (2656458) 2656458..2656994 - 537 WP_000429147.1 DNA-binding transcriptional regulator SutR -
M9O74_RS12945 (2657086) 2657086..2658258 + 1173 WP_032284782.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T246132 WP_000813796.1 NZ_CP097719:c2653880-2653704 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLN

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15219.59 Da        Isoelectric Point: 4.5908

>AT246132 WP_076838470.1 NZ_CP097719:c2653660-2653244 [Escherichia coli]
MRYPVTLTPAPEGGYVVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5F1EUB3

Antitoxin

Source ID Structure

References