Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1518925..1519550 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag M9O74_RS07415 Protein ID WP_000911329.1
Coordinates 1519152..1519550 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag M9O74_RS07410 Protein ID WP_000450524.1
Coordinates 1518925..1519152 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS07385 (1514725) 1514725..1515195 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
M9O74_RS07390 (1515195) 1515195..1515767 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
M9O74_RS07395 (1515913) 1515913..1516791 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
M9O74_RS07400 (1516808) 1516808..1517842 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
M9O74_RS07405 (1518055) 1518055..1518768 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
M9O74_RS07410 (1518925) 1518925..1519152 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
M9O74_RS07415 (1519152) 1519152..1519550 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
M9O74_RS07420 (1519697) 1519697..1520560 + 864 WP_001267498.1 neutral zinc metallopeptidase -
M9O74_RS07425 (1520575) 1520575..1522590 + 2016 WP_000829310.1 tRNA cytosine(34) acetyltransferase TmcA -
M9O74_RS07430 (1522664) 1522664..1523362 + 699 WP_025491901.1 esterase -
M9O74_RS07435 (1523443) 1523443..1523643 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T246124 WP_000911329.1 NZ_CP097719:1519152-1519550 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT246124 WP_000450524.1 NZ_CP097719:1518925-1519152 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References