Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1071645..1072299 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag M9O74_RS05375 Protein ID WP_000244781.1
Coordinates 1071892..1072299 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M9O74_RS05370 Protein ID WP_000354046.1
Coordinates 1071645..1071911 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS05350 (1067723) 1067723..1069156 - 1434 WP_001389468.1 6-phospho-beta-glucosidase BglA -
M9O74_RS05355 (1069201) 1069201..1069512 + 312 WP_001182953.1 N(4)-acetylcytidine aminohydrolase -
M9O74_RS05360 (1069676) 1069676..1070335 + 660 WP_000250269.1 hemolysin III family protein -
M9O74_RS05365 (1070412) 1070412..1071392 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
M9O74_RS05370 (1071645) 1071645..1071911 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M9O74_RS05375 (1071892) 1071892..1072299 + 408 WP_000244781.1 protein YgfX Toxin
M9O74_RS05380 (1072339) 1072339..1072860 - 522 WP_001055874.1 flavodoxin FldB -
M9O74_RS05385 (1072972) 1072972..1073868 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M9O74_RS05390 (1073893) 1073893..1074603 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M9O74_RS05395 (1074609) 1074609..1076342 + 1734 WP_000813191.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T246123 WP_000244781.1 NZ_CP097719:1071892-1072299 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT246123 WP_000354046.1 NZ_CP097719:1071645-1071911 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References