Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 161876..162501 Replicon plasmid pMS1718-1
Accession NZ_CP097717
Organism Escherichia coli strain MS1718

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M9O77_RS25340 Protein ID WP_000911313.1
Coordinates 161876..162274 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag M9O77_RS25345 Protein ID WP_000450520.1
Coordinates 162274..162501 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O77_RS25325 (158201) 158201..158698 + 498 WP_000605857.1 entry exclusion protein -
M9O77_RS25330 (158730) 158730..159461 + 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
M9O77_RS25335 (159714) 159714..161867 + 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
M9O77_RS25340 (161876) 161876..162274 - 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
M9O77_RS25345 (162274) 162274..162501 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid qnrS1 / tet(A) / sitABCD vat / iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA 1..170336 170336


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T246115 WP_000911313.1 NZ_CP097717:c162274-161876 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT246115 WP_000450520.1 NZ_CP097717:c162501-162274 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References