Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | V | Classification (family/domain) | ghoTS/ghoT-GhoS |
Location | 4612433..4612930 | Replicon | chromosome |
Accession | NZ_CP097716 | ||
Organism | Escherichia coli strain MS1718 |
Toxin (Protein)
Gene name | ghoT | Uniprot ID | L4JJG6 |
Locus tag | M9O77_RS22070 | Protein ID | WP_001173343.1 |
Coordinates | 4612433..4612606 (-) | Length | 58 a.a. |
Antitoxin (Protein)
Gene name | ghoS | Uniprot ID | L4JK92 |
Locus tag | M9O77_RS22075 | Protein ID | WP_000398619.1 |
Coordinates | 4612634..4612930 (-) | Length | 99 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M9O77_RS22060 (4609103) | 4609103..4610560 | + | 1458 | WP_022646457.1 | dipeptide/tripeptide permease DtpC | - |
M9O77_RS22065 (4610797) | 4610797..4612314 | + | 1518 | WP_000003800.1 | lysine--tRNA ligase | - |
M9O77_RS22070 (4612433) | 4612433..4612606 | - | 174 | WP_001173343.1 | type V toxin-antitoxin system toxin GhoT | Toxin |
M9O77_RS22075 (4612634) | 4612634..4612930 | - | 297 | WP_000398619.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | Antitoxin |
M9O77_RS22080 (4613159) | 4613159..4613431 | - | 273 | WP_000405647.1 | GNAT family N-acetyltransferase | - |
M9O77_RS22085 (4613443) | 4613443..4613673 | - | 231 | WP_001683478.1 | 4Fe-4S mono-cluster protein YjdI | - |
M9O77_RS22090 (4613854) | 4613854..4615485 | + | 1632 | WP_022646455.1 | sensor histidine kinase | - |
M9O77_RS22095 (4615482) | 4615482..4616201 | + | 720 | WP_000611288.1 | two-component system response regulator DcuR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 4603579..4612930 | 9351 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QI41 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 2LLZ | |
AlphaFold DB | A0A7U9QBH6 |