246097

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3718446..3719064 Replicon chromosome
Accession NZ_CP097716
Organism Escherichia coli strain MS1718

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M9O77_RS17820 Protein ID WP_001291435.1
Coordinates 3718846..3719064 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M9O77_RS17815 Protein ID WP_000344800.1
Coordinates 3718446..3718820 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O77_RS17805 (3713535) 3713535..3714728 + 1194 WP_167821183.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M9O77_RS17810 (3714751) 3714751..3717900 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M9O77_RS17815 (3718446) 3718446..3718820 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M9O77_RS17820 (3718846) 3718846..3719064 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M9O77_RS17825 (3719236) 3719236..3719787 + 552 WP_000536391.1 maltose O-acetyltransferase -
M9O77_RS17830 (3719903) 3719903..3720373 + 471 WP_022645280.1 YlaC family protein -
M9O77_RS17835 (3720537) 3720537..3722087 + 1551 WP_012602175.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M9O77_RS17840 (3722128) 3722128..3722481 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M9O77_RS17850 (3722860) 3722860..3723171 + 312 WP_000409911.1 MGMT family protein -
M9O77_RS17855 (3723202) 3723202..3723774 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246097 WP_001291435.1 NZ_CP097716:3718846-3719064 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246097 WP_000344800.1 NZ_CP097716:3718446-3718820 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References