246094

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3001160..3001944 Replicon chromosome
Accession NZ_CP097716
Organism Escherichia coli strain MS1718

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag M9O77_RS14450 Protein ID WP_000613626.1
Coordinates 3001450..3001944 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag M9O77_RS14445 Protein ID WP_139352217.1
Coordinates 3001160..3001453 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O77_RS14435 (2996309) 2996309..2997268 - 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
M9O77_RS14440 (2997841) 2997841..3001026 + 3186 WP_077516769.1 ribonuclease E -
M9O77_RS14445 (3001160) 3001160..3001453 + 294 WP_139352217.1 DUF1778 domain-containing protein Antitoxin
M9O77_RS14450 (3001450) 3001450..3001944 + 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
M9O77_RS14455 (3002039) 3002039..3002992 - 954 WP_001212763.1 flagellar hook-associated protein FlgL -
M9O77_RS14460 (3003004) 3003004..3004647 - 1644 WP_077516765.1 flagellar hook-associated protein FlgK -
M9O77_RS14465 (3004713) 3004713..3005654 - 942 WP_012311956.1 flagellar assembly peptidoglycan hydrolase FlgJ -
M9O77_RS14470 (3005654) 3005654..3006751 - 1098 WP_000589300.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-95)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T246094 WP_000613626.1 NZ_CP097716:3001450-3001944 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11139.76 Da        Isoelectric Point: 10.5423

>AT246094 WP_139352217.1 NZ_CP097716:3001160-3001453 [Escherichia coli]
MPAANNIPARREFLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure

References