Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2597849..2598487 Replicon chromosome
Accession NZ_CP097716
Organism Escherichia coli strain MS1718

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag M9O77_RS12435 Protein ID WP_000813794.1
Coordinates 2598311..2598487 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M9O77_RS12430 Protein ID WP_001270286.1
Coordinates 2597849..2598265 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O77_RS12410 (2593001) 2593001..2593942 - 942 WP_088129997.1 ABC transporter permease -
M9O77_RS12415 (2593943) 2593943..2594956 - 1014 WP_022645666.1 ABC transporter ATP-binding protein -
M9O77_RS12420 (2594974) 2594974..2596119 - 1146 WP_000047466.1 ABC transporter substrate-binding protein -
M9O77_RS12425 (2596364) 2596364..2597770 - 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
M9O77_RS12430 (2597849) 2597849..2598265 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M9O77_RS12435 (2598311) 2598311..2598487 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M9O77_RS12440 (2598709) 2598709..2598939 + 231 WP_000491567.1 DUF2554 family protein -
M9O77_RS12445 (2599031) 2599031..2600992 - 1962 WP_023909195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M9O77_RS12450 (2601065) 2601065..2601601 - 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
M9O77_RS12455 (2601693) 2601693..2602865 + 1173 WP_022645663.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T246093 WP_000813794.1 NZ_CP097716:c2598487-2598311 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT246093 WP_001270286.1 NZ_CP097716:c2598265-2597849 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References