246086

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1005313..1005967 Replicon chromosome
Accession NZ_CP097716
Organism Escherichia coli strain MS1718

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag M9O77_RS04830 Protein ID WP_000244781.1
Coordinates 1005560..1005967 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M9O77_RS04825 Protein ID WP_000354046.1
Coordinates 1005313..1005579 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O77_RS04800 (1000604) 1000604..1001353 + 750 WP_209319277.1 transporter -
M9O77_RS04805 (1001401) 1001401..1002834 - 1434 WP_136698981.1 6-phospho-beta-glucosidase BglA -
M9O77_RS04810 (1002879) 1002879..1003190 + 312 WP_077516667.1 N(4)-acetylcytidine aminohydrolase -
M9O77_RS04815 (1003354) 1003354..1004013 + 660 WP_000250269.1 hemolysin III family protein -
M9O77_RS04820 (1004090) 1004090..1005070 - 981 WP_077516665.1 tRNA-modifying protein YgfZ -
M9O77_RS04825 (1005313) 1005313..1005579 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M9O77_RS04830 (1005560) 1005560..1005967 + 408 WP_000244781.1 protein YgfX Toxin
M9O77_RS04835 (1006007) 1006007..1006528 - 522 WP_032303736.1 flavodoxin FldB -
M9O77_RS04840 (1006640) 1006640..1007536 + 897 WP_000806650.1 site-specific tyrosine recombinase XerD -
M9O77_RS04845 (1007561) 1007561..1008271 + 711 WP_077516663.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M9O77_RS04850 (1008277) 1008277..1010010 + 1734 WP_077516661.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T246086 WP_000244781.1 NZ_CP097716:1005560-1005967 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT246086 WP_000354046.1 NZ_CP097716:1005313-1005579 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References