Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 112723..113248 Replicon plasmid pMS1718-1
Accession NZ_CP097712
Organism Escherichia coli strain MS1737

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag M9O76_RS23860 Protein ID WP_001159871.1
Coordinates 112723..113028 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag M9O76_RS23865 Protein ID WP_000813630.1
Coordinates 113030..113248 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O76_RS23845 (108679) 108679..109884 - 1206 WP_001442122.1 AAA family ATPase -
M9O76_RS23850 (110505) 110505..111236 + 732 WP_011402755.1 replication initiation protein -
M9O76_RS23855 (111916) 111916..112722 - 807 WP_000016968.1 site-specific integrase -
M9O76_RS23860 (112723) 112723..113028 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
M9O76_RS23865 (113030) 113030..113248 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
M9O76_RS23870 (113834) 113834..114064 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
M9O76_RS23875 (114061) 114061..114477 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD vat / iucA / iucB / iucC / iucD / iutA / iroB / iroC / iroD / iroE / iroN 1..188685 188685


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T246074 WP_001159871.1 NZ_CP097712:c113028-112723 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8354.27 Da        Isoelectric Point: 4.5203

>AT246074 WP_000813630.1 NZ_CP097712:c113248-113030 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTLQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References