Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /Xre(antitoxin) |
Location | 5012747..5014004 | Replicon | chromosome |
Accession | NZ_CP097710 | ||
Organism | Pseudomonas aeruginosa strain PA-2 |
Toxin (Protein)
Gene name | - | Uniprot ID | - |
Locus tag | M8342_RS23665 | Protein ID | WP_003449003.1 |
Coordinates | 5012747..5013502 (-) | Length | 252 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | V6AJU7 |
Locus tag | M8342_RS23670 | Protein ID | WP_003086329.1 |
Coordinates | 5013636..5014004 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M8342_RS23655 (M8342_23655) | 5007920..5010463 | + | 2544 | WP_034037613.1 | acyl-homoserine-lactone acylase QuiP | - |
M8342_RS23660 (M8342_23660) | 5010618..5011979 | - | 1362 | WP_003081943.1 | DNA recombination protein RmuC | - |
M8342_RS23665 (M8342_23665) | 5012747..5013502 | - | 756 | WP_003449003.1 | RES family NAD+ phosphorylase | Toxin |
M8342_RS23670 (M8342_23670) | 5013636..5014004 | - | 369 | WP_003086329.1 | DUF2384 domain-containing protein | Antitoxin |
M8342_RS23675 (M8342_23675) | 5014077..5015363 | - | 1287 | WP_003112529.1 | FAD-binding oxidoreductase | - |
M8342_RS23680 (M8342_23680) | 5015419..5017008 | - | 1590 | WP_003123191.1 | aldehyde dehydrogenase family protein | - |
M8342_RS23685 (M8342_23685) | 5017087..5017563 | + | 477 | WP_003112531.1 | hypothetical protein | - |
M8342_RS23690 (M8342_23690) | 5017566..5017841 | - | 276 | WP_169057979.1 | zinc ribbon domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 252 a.a. Molecular weight: 28292.45 Da Isoelectric Point: 7.7294
>T246050 WP_003449003.1 NZ_CP097710:c5013502-5012747 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA
Download Length: 756 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13367.63 Da Isoelectric Point: 9.9874
>AT246050 WP_003086329.1 NZ_CP097710:c5014004-5013636 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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