Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5012747..5014004 Replicon chromosome
Accession NZ_CP097710
Organism Pseudomonas aeruginosa strain PA-2

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M8342_RS23665 Protein ID WP_003449003.1
Coordinates 5012747..5013502 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M8342_RS23670 Protein ID WP_003086329.1
Coordinates 5013636..5014004 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8342_RS23655 (M8342_23655) 5007920..5010463 + 2544 WP_034037613.1 acyl-homoserine-lactone acylase QuiP -
M8342_RS23660 (M8342_23660) 5010618..5011979 - 1362 WP_003081943.1 DNA recombination protein RmuC -
M8342_RS23665 (M8342_23665) 5012747..5013502 - 756 WP_003449003.1 RES family NAD+ phosphorylase Toxin
M8342_RS23670 (M8342_23670) 5013636..5014004 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M8342_RS23675 (M8342_23675) 5014077..5015363 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
M8342_RS23680 (M8342_23680) 5015419..5017008 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
M8342_RS23685 (M8342_23685) 5017087..5017563 + 477 WP_003112531.1 hypothetical protein -
M8342_RS23690 (M8342_23690) 5017566..5017841 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28292.45 Da        Isoelectric Point: 7.7294

>T246050 WP_003449003.1 NZ_CP097710:c5013502-5012747 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT246050 WP_003086329.1 NZ_CP097710:c5014004-5013636 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References