Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 4075580..4076801 | Replicon | chromosome |
Accession | NZ_CP097710 | ||
Organism | Pseudomonas aeruginosa strain PA-2 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0C7CS07 |
Locus tag | M8342_RS19290 | Protein ID | WP_003102740.1 |
Coordinates | 4076223..4076801 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | M8342_RS19285 | Protein ID | WP_003088112.1 |
Coordinates | 4075580..4076134 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M8342_RS19260 (M8342_19260) | 4071148..4071699 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
M8342_RS19265 (M8342_19265) | 4071696..4072094 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
M8342_RS19270 (M8342_19270) | 4072107..4072430 | - | 324 | WP_034038313.1 | multidrug efflux SMR transporter | - |
M8342_RS19275 (M8342_19275) | 4072761..4073222 | + | 462 | WP_034038312.1 | (2Fe-2S)-binding protein | - |
M8342_RS19280 (M8342_19280) | 4073227..4075422 | + | 2196 | WP_003122807.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
M8342_RS19285 (M8342_19285) | 4075580..4076134 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
M8342_RS19290 (M8342_19290) | 4076223..4076801 | + | 579 | WP_003102740.1 | HD domain-containing protein | Toxin |
M8342_RS19295 (M8342_19295) | 4076910..4078097 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
M8342_RS19300 (M8342_19300) | 4078087..4080258 | - | 2172 | WP_034038311.1 | type I secretion system permease/ATPase | - |
M8342_RS19305 (M8342_19305) | 4080248..4081525 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21869.70 Da Isoelectric Point: 5.3655
>T246049 WP_003102740.1 NZ_CP097710:4076223-4076801 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT246049 WP_003088112.1 NZ_CP097710:4075580-4076134 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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