246048

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2505198..2506240 Replicon chromosome
Accession NZ_CP097710
Organism Pseudomonas aeruginosa strain PA-2

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag M8342_RS12005 Protein ID WP_003153636.1
Coordinates 2505665..2506240 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag M8342_RS12000 Protein ID WP_003050245.1
Coordinates 2505198..2505668 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8342_RS11965 (M8342_11960) 2500590..2502008 - 1419 WP_023100422.1 TIGR03752 family integrating conjugative element protein -
M8342_RS11970 (M8342_11965) 2501998..2502909 - 912 WP_023100423.1 TIGR03749 family integrating conjugative element protein -
M8342_RS11975 (M8342_11970) 2502906..2503598 - 693 WP_023100424.1 TIGR03746 family integrating conjugative element protein -
M8342_RS11980 (M8342_11975) 2503595..2503993 - 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
M8342_RS11985 (M8342_11980) 2504005..2504364 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
M8342_RS11990 (M8342_11985) 2504381..2504614 - 234 WP_003090170.1 TIGR03758 family integrating conjugative element protein -
M8342_RS11995 (M8342_11990) 2504611..2504994 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
M8342_RS12000 (M8342_11995) 2505198..2505668 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
M8342_RS12005 (M8342_12000) 2505665..2506240 + 576 WP_003153636.1 PIN domain-containing protein Toxin
M8342_RS12010 (M8342_12005) 2506258..2507172 + 915 WP_016852809.1 AAA family ATPase -
M8342_RS12015 (M8342_12010) 2507169..2507639 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
M8342_RS12020 (M8342_12015) 2507636..2508136 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
M8342_RS12025 (M8342_12020) 2508136..2509038 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
M8342_RS12030 (M8342_12025) 2509077..2509802 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2415305..2552355 137050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T246048 WP_003153636.1 NZ_CP097710:2505665-2506240 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT246048 WP_003050245.1 NZ_CP097710:2505198-2505668 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References