Detailed information of TA system TA246046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1938193..1939701
• Replicon: chromosome
• Accession: NZ_CP097710
• Organism: Pseudomonas aeruginosa strain PA-2

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: M8342_RS09220
• Protein ID: WP_012613851.1
• Coordinates: 1938193..1938780 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: M8342_RS09225
• Protein ID: WP_012613852.1
• Coordinates: 1938847..1939701 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M8342_RS09215 (M8342_09210)	1934448..1937927	-	3480	WP_023115144.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
M8342_RS09220 (M8342_09215)	1938193..1938780	+	588	WP_012613851.1	GNAT family protein	Toxin
M8342_RS09225 (M8342_09220)	1938847..1939701	+	855	WP_012613852.1	AraC family transcriptional regulator	Antitoxin
M8342_RS09230 (M8342_09225)	1939798..1941963	+	2166	WP_003091606.1	TonB-dependent receptor family protein	-
M8342_RS09235 (M8342_09230)	1942138..1944012	+	1875	WP_003117607.1	MFS transporter	-
M8342_RS09240 (M8342_09235)	1944073..1944282	-	210	WP_003115568.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21929.29 Da
• Isoelectric Point: 9.8676

>T246046 WP_012613851.1 NZ_CP097710:1938193-1938780 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Nucleotide

• Length: 588 bp

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31959.27 Da
• Isoelectric Point: 7.3276

>AT246046 WP_012613852.1 NZ_CP097710:1938847-1939701 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Nucleotide

• Length: 855 bp