Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 161966..162471 Replicon chromosome
Accession NZ_CP097710
Organism Pseudomonas aeruginosa strain PA-2

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag M8342_RS00735 Protein ID WP_034037564.1
Coordinates 161966..162247 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag M8342_RS00740 Protein ID WP_003083775.1
Coordinates 162244..162471 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8342_RS00710 (M8342_00710) 157217..158566 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
M8342_RS00715 (M8342_00715) 158615..159301 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
M8342_RS00720 (M8342_00720) 159402..160136 + 735 WP_003117208.1 GntR family transcriptional regulator -
M8342_RS00725 (M8342_00725) 160316..160726 + 411 WP_003101225.1 aegerolysin family protein -
M8342_RS00730 (M8342_00730) 160758..161666 - 909 WP_016561475.1 LysR family transcriptional regulator -
M8342_RS00735 (M8342_00735) 161966..162247 - 282 WP_034037564.1 type II toxin-antitoxin system toxin ParE Toxin
M8342_RS00740 (M8342_00740) 162244..162471 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
M8342_RS00745 (M8342_00745) 162647..163267 - 621 WP_003101226.1 hypothetical protein -
M8342_RS00750 (M8342_00750) 163368..163868 + 501 WP_003101228.1 LEA type 2 family protein -
M8342_RS00755 (M8342_00755) 163941..164282 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
M8342_RS00760 (M8342_00760) 164364..165791 - 1428 WP_003083784.1 GABA permease -
M8342_RS00765 (M8342_00765) 165960..167453 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10458.20 Da        Isoelectric Point: 10.0435

>T246045 WP_034037564.1 NZ_CP097710:c162247-161966 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT246045 WP_003083775.1 NZ_CP097710:c162471-162244 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References