Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 4074477..4075698 | Replicon | chromosome |
Accession | NZ_CP097709 | ||
Organism | Pseudomonas aeruginosa strain PA-1 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0C7CS07 |
Locus tag | M8341_RS19285 | Protein ID | WP_003102740.1 |
Coordinates | 4075120..4075698 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | M8341_RS19280 | Protein ID | WP_003088112.1 |
Coordinates | 4074477..4075031 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M8341_RS19255 (M8341_19250) | 4070045..4070596 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
M8341_RS19260 (M8341_19255) | 4070593..4070991 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
M8341_RS19265 (M8341_19260) | 4071004..4071327 | - | 324 | WP_034038313.1 | multidrug efflux SMR transporter | - |
M8341_RS19270 (M8341_19265) | 4071658..4072119 | + | 462 | WP_034038312.1 | (2Fe-2S)-binding protein | - |
M8341_RS19275 (M8341_19270) | 4072124..4074319 | + | 2196 | WP_003122807.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
M8341_RS19280 (M8341_19275) | 4074477..4075031 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
M8341_RS19285 (M8341_19280) | 4075120..4075698 | + | 579 | WP_003102740.1 | HD domain-containing protein | Toxin |
M8341_RS19290 (M8341_19285) | 4075807..4076994 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
M8341_RS19295 (M8341_19290) | 4076984..4079155 | - | 2172 | WP_034038311.1 | type I secretion system permease/ATPase | - |
M8341_RS19300 (M8341_19295) | 4079145..4080422 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21869.70 Da Isoelectric Point: 5.3655
>T246042 WP_003102740.1 NZ_CP097709:4075120-4075698 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT246042 WP_003088112.1 NZ_CP097709:4074477-4075031 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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