Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4074477..4075698 Replicon chromosome
Accession NZ_CP097709
Organism Pseudomonas aeruginosa strain PA-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag M8341_RS19285 Protein ID WP_003102740.1
Coordinates 4075120..4075698 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M8341_RS19280 Protein ID WP_003088112.1
Coordinates 4074477..4075031 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8341_RS19255 (M8341_19250) 4070045..4070596 + 552 WP_003102727.1 XRE family transcriptional regulator -
M8341_RS19260 (M8341_19255) 4070593..4070991 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M8341_RS19265 (M8341_19260) 4071004..4071327 - 324 WP_034038313.1 multidrug efflux SMR transporter -
M8341_RS19270 (M8341_19265) 4071658..4072119 + 462 WP_034038312.1 (2Fe-2S)-binding protein -
M8341_RS19275 (M8341_19270) 4072124..4074319 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M8341_RS19280 (M8341_19275) 4074477..4075031 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M8341_RS19285 (M8341_19280) 4075120..4075698 + 579 WP_003102740.1 HD domain-containing protein Toxin
M8341_RS19290 (M8341_19285) 4075807..4076994 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
M8341_RS19295 (M8341_19290) 4076984..4079155 - 2172 WP_034038311.1 type I secretion system permease/ATPase -
M8341_RS19300 (M8341_19295) 4079145..4080422 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T246042 WP_003102740.1 NZ_CP097709:4075120-4075698 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT246042 WP_003088112.1 NZ_CP097709:4074477-4075031 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References