246041

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2504095..2505137 Replicon chromosome
Accession NZ_CP097709
Organism Pseudomonas aeruginosa strain PA-1

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag M8341_RS11995 Protein ID WP_003153636.1
Coordinates 2504562..2505137 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag M8341_RS11990 Protein ID WP_003050245.1
Coordinates 2504095..2504565 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8341_RS11955 (M8341_11950) 2499487..2500905 - 1419 WP_023100422.1 TIGR03752 family integrating conjugative element protein -
M8341_RS11960 (M8341_11955) 2500895..2501806 - 912 WP_023100423.1 TIGR03749 family integrating conjugative element protein -
M8341_RS11965 (M8341_11960) 2501803..2502495 - 693 WP_023100424.1 TIGR03746 family integrating conjugative element protein -
M8341_RS11970 (M8341_11965) 2502492..2502890 - 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
M8341_RS11975 (M8341_11970) 2502902..2503261 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
M8341_RS11980 (M8341_11975) 2503278..2503511 - 234 WP_003090170.1 TIGR03758 family integrating conjugative element protein -
M8341_RS11985 (M8341_11980) 2503508..2503891 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
M8341_RS11990 (M8341_11985) 2504095..2504565 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
M8341_RS11995 (M8341_11990) 2504562..2505137 + 576 WP_003153636.1 PIN domain-containing protein Toxin
M8341_RS12000 (M8341_11995) 2505155..2506069 + 915 WP_016852809.1 AAA family ATPase -
M8341_RS12005 (M8341_12000) 2506066..2506536 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
M8341_RS12010 (M8341_12005) 2506533..2507033 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
M8341_RS12015 (M8341_12010) 2507033..2507935 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
M8341_RS12020 (M8341_12015) 2507974..2508699 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2414202..2551252 137050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T246041 WP_003153636.1 NZ_CP097709:2504562-2505137 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT246041 WP_003050245.1 NZ_CP097709:2504095-2504565 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References