Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1938193..1939701 Replicon chromosome
Accession NZ_CP097709
Organism Pseudomonas aeruginosa strain PA-1

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M8341_RS09220 Protein ID WP_012613851.1
Coordinates 1938193..1938780 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag M8341_RS09225 Protein ID WP_012613852.1
Coordinates 1938847..1939701 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8341_RS09215 (M8341_09210) 1934448..1937927 - 3480 WP_023115144.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
M8341_RS09220 (M8341_09215) 1938193..1938780 + 588 WP_012613851.1 GNAT family protein Toxin
M8341_RS09225 (M8341_09220) 1938847..1939701 + 855 WP_012613852.1 AraC family transcriptional regulator Antitoxin
M8341_RS09230 (M8341_09225) 1939798..1941963 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
M8341_RS09235 (M8341_09230) 1942138..1944012 + 1875 WP_003117607.1 MFS transporter -
M8341_RS09240 (M8341_09235) 1944073..1944282 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21929.29 Da        Isoelectric Point: 9.8676

>T246039 WP_012613851.1 NZ_CP097709:1938193-1938780 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31959.27 Da        Isoelectric Point: 7.3276

>AT246039 WP_012613852.1 NZ_CP097709:1938847-1939701 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References