Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 128178..128821 Replicon plasmid unnamed4
Accession NZ_CP097707
Organism Klebsiella pneumoniae strain IR12197_1

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag M3X87_RS29225 Protein ID WP_001044770.1
Coordinates 128178..128594 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag M3X87_RS29230 Protein ID WP_001261282.1
Coordinates 128591..128821 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X87_RS29205 (124281) 124281..124553 - 273 Protein_151 transposase -
M3X87_RS29215 (125535) 125535..126557 - 1023 WP_000361404.1 helicase UvrD -
M3X87_RS29220 (126542) 126542..128104 - 1563 WP_004206609.1 AAA family ATPase -
M3X87_RS29225 (128178) 128178..128594 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
M3X87_RS29230 (128591) 128591..128821 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M3X87_RS29235 (128778) 128778..129239 + 462 WP_014343465.1 hypothetical protein -
M3X87_RS29240 (129400) 129400..130343 + 944 Protein_158 hypothetical protein -
M3X87_RS29245 (130380) 130380..130772 + 393 WP_011977811.1 hypothetical protein -
M3X87_RS29250 (130830) 130830..131351 + 522 WP_013214008.1 hypothetical protein -
M3X87_RS29255 (131397) 131397..131600 + 204 WP_011977813.1 hypothetical protein -
M3X87_RS29260 (131630) 131630..132634 + 1005 WP_011977814.1 hypothetical protein -
M3X87_RS29265 (132818) 132818..133597 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-65 / rmtB / blaKPC-2 - 1..159393 159393


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T246037 WP_001044770.1 NZ_CP097707:c128594-128178 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT246037 WP_001261282.1 NZ_CP097707:c128821-128591 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References