Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2704296..2705884 Replicon chromosome
Accession NZ_CP097703
Organism Klebsiella pneumoniae strain IR12197_1

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag M3X87_RS13380 Protein ID WP_004199851.1
Coordinates 2704296..2705618 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag M3X87_RS13385 Protein ID WP_002904790.1
Coordinates 2705618..2705884 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X87_RS13365 (M3X87_13365) 2699361..2701862 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
M3X87_RS13370 (M3X87_13370) 2701850..2702854 + 1005 WP_004199852.1 fimbrial protein -
M3X87_RS13375 (M3X87_13375) 2702987..2704279 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M3X87_RS13380 (M3X87_13380) 2704296..2705618 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
M3X87_RS13385 (M3X87_13385) 2705618..2705884 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M3X87_RS13390 (M3X87_13390) 2706150..2706476 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M3X87_RS13395 (M3X87_13395) 2706473..2706973 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M3X87_RS13400 (M3X87_13400) 2706951..2708330 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
M3X87_RS13405 (M3X87_13405) 2708676..2709830 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M3X87_RS13410 (M3X87_13410) 2709811..2710734 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T246026 WP_004199851.1 NZ_CP097703:c2705618-2704296 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT246026 WP_002904790.1 NZ_CP097703:c2705884-2705618 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References