Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 713179..713954 Replicon chromosome
Accession NZ_CP097703
Organism Klebsiella pneumoniae strain IR12197_1

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag M3X87_RS03550 Protein ID WP_004150910.1
Coordinates 713469..713954 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M3X87_RS03545 Protein ID WP_004150912.1
Coordinates 713179..713472 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X87_RS03525 (M3X87_03525) 708310..709221 + 912 WP_004188550.1 LysR family transcriptional regulator -
M3X87_RS03530 (M3X87_03530) 709222..710370 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
M3X87_RS03535 (M3X87_03535) 710381..711757 - 1377 WP_004217775.1 cystathionine beta-synthase -
M3X87_RS03545 (M3X87_03545) 713179..713472 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M3X87_RS03550 (M3X87_03550) 713469..713954 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
M3X87_RS03555 (M3X87_03555) 714658..715251 + 594 WP_133400560.1 hypothetical protein -
M3X87_RS03560 (M3X87_03560) 715348..715564 + 217 Protein_699 transposase -
M3X87_RS03565 (M3X87_03565) 716170..717042 + 873 WP_004188557.1 ParA family protein -
M3X87_RS03570 (M3X87_03570) 717042..717425 + 384 WP_004150906.1 hypothetical protein -
M3X87_RS03575 (M3X87_03575) 717418..718785 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 712136..715500 3364


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T246020 WP_004150910.1 NZ_CP097703:713469-713954 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT246020 WP_004150912.1 NZ_CP097703:713179-713472 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References