Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 743251..743837 Replicon chromosome
Accession NC_013928
Organism Streptococcus mutans NN2025

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J9QEE1
Locus tag SMUNN2025_RS03685 Protein ID WP_002264916.1
Coordinates 743251..743442 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0A8KA30
Locus tag SMUNN2025_RS03690 Protein ID WP_002265422.1
Coordinates 743460..743837 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMUNN2025_RS03670 741295..742161 + 867 WP_002277363.1 type II CRISPR-associated endonuclease Cas1 -
SMUNN2025_RS03675 742158..742502 + 345 WP_002263547.1 CRISPR-associated endonuclease Cas2 -
SMUNN2025_RS03680 742492..743154 + 663 WP_002275427.1 type II-A CRISPR-associated protein Csn2 -
SMUNN2025_RS03685 743251..743442 + 192 WP_002264916.1 type II toxin-antitoxin system HicA family toxin Toxin
SMUNN2025_RS03690 743460..743837 + 378 WP_002265422.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-107)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7149.51 Da        Isoelectric Point: 10.6223

>T24597 WP_002264916.1 NC_013928:743251-743442 [Streptococcus mutans NN2025]
MPLTGKELAKLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Download         Length: 192 bp

>T24597 NC_013928:743251-743442 [Streptococcus mutans NN2025]
TTGCCATTAACAGGGAAAGAATTAGCTAAATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTACCTTATATTGTGACGATTCCCATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14335.32 Da        Isoelectric Point: 4.5628

>AT24597 WP_002265422.1 NC_013928:743460-743837 [Streptococcus mutans NN2025]
MLKTYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALERKLQL

Download         Length: 378 bp

>AT24597 NC_013928:743460-743837 [Streptococcus mutans NN2025]
ATGTTAAAAACATATCCTGCAATTTTTCATAAGGAAGAGGAAGGATATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTATTGGCCTCCTATCTAGATGAGG
GAATGAAACTGCCTAATCCAAGTGAGATAAGGAAACTATCTGTTGAAGATGGCTTTGCAACTATGATTCAAGCAGATCCT
AATCCTTATCTCAAAAATAACAAAGCTATTCGAAAGAATGTTACCGTACCTGAGTGGCTAGTACAATTAGCAGATCGTGA
TCAAGTGAATTATTCTGAAGTATTAACAAAAGCTTTGGAAAGGAAACTACAATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QEE1

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8KA30

References