Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4936860..4937376 Replicon chromosome
Accession NZ_CP097692
Organism Klebsiella pneumoniae strain IR12094_1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag M3T51_RS24455 Protein ID WP_002886902.1
Coordinates 4936860..4937144 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M3T51_RS24460 Protein ID WP_002886901.1
Coordinates 4937134..4937376 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3T51_RS24430 (M3T51_24430) 4932344..4932607 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
M3T51_RS24435 (M3T51_24435) 4932737..4932910 + 174 WP_002886906.1 hypothetical protein -
M3T51_RS24440 (M3T51_24440) 4932913..4933656 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M3T51_RS24445 (M3T51_24445) 4934013..4936151 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
M3T51_RS24450 (M3T51_24450) 4936392..4936856 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M3T51_RS24455 (M3T51_24455) 4936860..4937144 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3T51_RS24460 (M3T51_24460) 4937134..4937376 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3T51_RS24465 (M3T51_24465) 4937454..4939364 - 1911 WP_004152270.1 PRD domain-containing protein -
M3T51_RS24470 (M3T51_24470) 4939387..4940541 - 1155 WP_002886900.1 lactonase family protein -
M3T51_RS24475 (M3T51_24475) 4940607..4941347 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T245967 WP_002886902.1 NZ_CP097692:c4937144-4936860 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245967 WP_002886901.1 NZ_CP097692:c4937376-4937134 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References